Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1701115 | 0.77 | KDM4E (0.44) | KDM4EMEN1KMT2AGAAHDAC4 | |
| SCHEMBL12073041 | 0.73 | HDAC4 (0.45) | KDM4EMEN1KMT2AHDAC4HDAC7 | |
| Hydrochloric Acid SCHEMBL1700922 | 0.72 | HDAC4 (0.44) | KDM4EMEN1KMT2AHDAC4HDAC7 | |
| SCHEMBL1701044 | 0.66 | CHRM3 (0.53) | MAPT | |
| SCHEMBL1701043 | 0.66 | CHRM3 (0.53) | MAPT | |
| SCHEMBL1695890 | 0.65 | KDM4E (0.56) | ATMKDM4EMEN1KMT2AGAA | |
| SCHEMBL28089881 | 0.64 | HDAC4 (0.41) | ATMKDM4EMEN1KMT2AGAA | |
| SCHEMBL2484626 | 0.63 | KDM4E (0.47) | KDM4EMEN1KMT2AHDAC4HDAC7 | |
| SCHEMBL13240783 | 0.63 | KDM4E (0.47) | KDM4EMEN1KMT2AHDAC4HDAC7 | |
| SCHEMBL13738674 | 0.62 | MEN1 (0.41) | L3MBTL1KDM4EMEN1PKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585459-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | Chiesi Farmaceutici S.p.A. (IT) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011161018-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |