Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | IL2 | P60568 | 1/20 | 0.56 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16994732 | 0.93 | TTR (0.55) | TTRIL2F2RL1GBA1OPRM1 | |
| SCHEMBL17874493 | 0.93 | TTR (0.55) | TTRIL2F2RL1GBA1OPRM1 | |
| SCHEMBL18772725 | 0.93 | TTR (0.55) | TTRIL2F2RL1GBA1OPRM1 | |
| SCHEMBL12342507 | 0.89 | TTR (0.51) | TTRIL2F2RL1OPRM1ALDH1A1 | |
| SCHEMBL30645075 | 0.85 | TTR (0.52) | TTRIL2F2RL1GBA1 | |
| SCHEMBL14129407 | 0.84 | TTR (0.45) | TTRIL2F2RL1GBA1OPRM1 | |
| SCHEMBL23425576 | 0.83 | TTR (0.47) | TTRIL2GBA1HPGDALDH1A1 | |
| SCHEMBL12342488 | 0.83 | TTR (0.46) | TTRIL2F2RL1OPRM1PKM | |
| SCHEMBL13684272 | 0.83 | TTR (0.46) | TTRIL2F2RL1OPRM1PKM | |
| SCHEMBL25559708 | 0.82 | TTR (0.45) | TTRIL2F2RL1GBA1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9107960-B2 | Antibody-SN-38 immunoconjugates with a CL2A linker | IMMUNIMEDICS, INC. (US) | 2015-08-18 | — | — | US | disclosed |