Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 11/20 | 0.33 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | IL1B | P01584 | 2/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1918969 | 0.90 | KDM4E (0.39) | KDM4EALDH1A1L3MBTL1MEN1LMNA | |
| SCHEMBL2245172 | 0.79 | KDM4E (0.39) | KDM4EALDH1A1L3MBTL1MEN1LMNA | |
| SCHEMBL2247032 | 0.79 | GSK3B (0.39) | KDM4EALDH1A1L3MBTL1MEN1LMNA | |
| SCHEMBL17012169 | 0.74 | KDM4E (0.36) | KDM4EALDH1A1L3MBTL1MEN1LMNA | |
| SCHEMBL2252780 | 0.73 | JAK3 (0.44) | KDM4EALDH1A1L3MBTL1MEN1LMNA | |
| SCHEMBL2249138 | 0.70 | KDM4E (0.42) | KDM4EALDH1A1L3MBTL1MEN1LMNA | |
| SCHEMBL1919317 | 0.70 | KDM4E (0.41) | KDM4EALDH1A1L3MBTL1MEN1LMNA | |
| SCHEMBL1919395 | 0.69 | GSK3B (0.48) | KDM4ETDP1GSK3BBTKIL1B | |
| SCHEMBL2243917 | 0.69 | JAK3 (0.44) | KDM4EALDH1A1L3MBTL1MEN1LMNA | |
| SCHEMBL2252675 | 0.69 | JAK3 (0.42) | KDM4EALDH1A1L3MBTL1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326639-B1 | SUBSTITUTED PYRIDINES AND ITS USE AS GSK3 INHIBITORS | BAYER IP GMBH (DE) | 2015-08-19 | — | — | EP | disclosed |