Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AOC2 | O75106 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL890923 | 0.86 | NQO1 (0.47) | APPIDO1CYP1A2CYP2C19TDP1 | |
| SCHEMBL11868582 | 0.78 | MAOB (0.50) | MAOBAPPCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9114592 | 0.78 | CYP1A2 (0.63) | MAOBAPPCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10338308 | 0.76 | MEN1 (0.60) | CYP1A2CYP2D6CYP2C19TDP1L3MBTL1 | |
| SCHEMBL7867839 | 0.76 | NQO1 (0.39) | APPIDO1TDP1 | |
| SCHEMBL14014285 | 0.74 | MAOB (0.57) | MAOBAPPCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3943214 | 0.74 | IDO1 (0.58) | MAOBAPPIDO1TDP1L3MBTL1 | |
| SCHEMBL1547683 | 0.74 | NQO1 (0.74) | MAOBCYP1A2CYP2D6CYP2C19TDP1 | |
| SCHEMBL2095927 | 0.74 | APP (0.52) | MAOBAPPCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9854868 | 0.74 | MAOB (0.47) | MAOBAPPCYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740579-B1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2015-08-19 | — | — | EP | disclosed |