Sugi Predict

Sugi Predict / Compounds / SCHEMBL1701329

SCHEMBL1701329

SCHEMBL1701329

Nc1ccc(-c2cc3c(cc2Cl)OCC3)cn1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DYRK1A Q13627 2/20 0.46
▸ PRKAB2 O43741 2/20 0.45
▸ PRKAG1 P54619 2/20 0.45
▸ PRKAA2 P54646 2/20 0.45
▸ PRKAA1 Q13131 2/20 0.45
▸ PRKAG3 Q9UGI9 2/20 0.45
▸ PRKAG2 Q9UGJ0 2/20 0.45
▸ PRKAB1 Q9Y478 2/20 0.45
▸ PIK3CD O00329 4/20 0.43
▸ FABP4 P15090 3/20 0.42
▸ MAP4K4 O95819 1/20 0.40
▸ CYP1A2 P05177 1/20 0.40
▸ KCNH2 Q12809 1/20 0.40
▸ MINK1 Q8N4C8 1/20 0.40
▸ TNIK Q9UKE5 1/20 0.40
▸ MAPT P10636 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ PI4K2A Q9BTU6 1/20 0.38
▸ MKNK1 Q9BUB5 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1701271 0.95 DYRK1A (0.46) DYRK1APRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL14226022 0.86 PIK3CD (0.47) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL1701285 0.84 DYRK1A (0.46) DYRK1APIK3CDFABP4TNIKMAPT
SCHEMBL17244774 0.81 DYRK1A (0.46) DYRK1APIK3CDFABP4MAPTRAB9A
SCHEMBL1701295 0.81 DYRK1A (0.46) DYRK1APIK3CDMAP4K4CYP1A2KCNH2
SCHEMBL1701261 0.80 ALOX5AP (0.38) DYRK1APRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL1701302 0.74 ALOX5AP (0.38) DYRK1APRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL1701752 0.72 STIM1 (0.56) PIK3CDMAP4K4CYP1A2KCNH2MINK1
SCHEMBL1701393 0.72 STIM1 (0.43) PIK3CDMAP4K4CYP1A2KCNH2MINK1
SCHEMBL17805346 0.71 PIK3CD (0.52) PIK3CDMAP4K4CYP1A2KCNH2MINK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11905248-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2024-02-20 — — US disclosed
US-20200317617-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM AVENUE CAPITAL MANAGEMENT II, L.P. 2020-10-08 — — US disclosed
US-20200317617-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM AVENUE CAPITAL MANAGEMENT II, L.P. 2020-10-08 — — US disclosed
US-10703722-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2020-07-07 — — US disclosed
US-10703722-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2020-07-07 — — US disclosed
EP-2563776-B1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC (US) 2016-06-08 — — EP disclosed
EP-2563776-B1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC (US) 2016-06-08 — — EP disclosed
US-20150322012-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM AVENUE CAPITAL MANAGEMENT II, L.P. 2015-11-12 — — US disclosed
US-20150322012-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM AVENUE CAPITAL MANAGEMENT II, L.P. 2015-11-12 — — US disclosed
US-9120751-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2015-09-01 — — US disclosed
US-8980629-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2015-03-17 — — US disclosed
US-20130345240-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2013-12-26 — — US disclosed
US-20130345193-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2013-12-26 — — US disclosed
US-8546403-B2 Compounds that modulate intracellular calcium CALCIMEDICA, INC. (US) 2013-10-01 — — US disclosed
EP-2563776-A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM Calcimedica, Inc. (US) 2013-03-06 — — EP disclosed
WO-2011139489-A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC. (US) 2011-11-10 — — WO disclosed
WO-2011139489-A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA INC. (US) 2011-11-10 — — WO disclosed
US-20110263612-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2011-10-27 — — US disclosed
US-20110263612-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2011-10-27 — — US disclosed
US-20110263612-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2011-10-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150322012-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 DYRK1A 3712/4885PRKAB2 521/4885PRKAG1 352/4885
US-10703722-B2 Compounds that modulate intracellular calcium ORAI1, SARAF, RYR2 DYRK1A 3712/4885PRKAB2 521/4885PRKAG1 352/4885
US-20110263612-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 DYRK1A 3712/4885PRKAB2 521/4885PRKAG1 352/4885
US-20130345193-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 DYRK1A 3712/4885PRKAB2 521/4885PRKAG1 352/4885
US-20200317617-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 DYRK1A 3712/4885PRKAB2 521/4885PRKAG1 352/4885
US-11905248-B2 Compounds that modulate intracellular calcium ORAI1, SARAF, RYR2 DYRK1A 3712/4885PRKAB2 521/4885PRKAG1 352/4885
US-20130345240-A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM ORAI1, SARAF, RYR2 DYRK1A 3712/4885PRKAB2 521/4885PRKAG1 352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.