Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 20/20 | 0.85 |
| ▸ | AKT1 | P31749 | 20/20 | 0.85 |
| ▸ | AKT2 | P31751 | 2/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16247301 | 0.92 | RPS6KB1 (1.00) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL16987133 | 0.92 | RPS6KB1 (0.97) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL14792364 | 0.92 | RPS6KB1 (1.00) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL14791635 | 0.92 | RPS6KB1 (0.87) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL16247302 | 0.91 | RPS6KB1 (1.00) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL14792365 | 0.91 | RPS6KB1 (0.79) | RPS6KB1AKT1 | |
| SCHEMBL16247265 | 0.91 | RPS6KB1 (0.86) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL16247266 | 0.91 | RPS6KB1 (0.88) | RPS6KB1AKT1 | |
| SCHEMBL16247267 | 0.90 | RPS6KB1 (0.84) | RPS6KB1AKT1AKT2KCNH2AKT3 | |
| SCHEMBL14792251 | 0.90 | RPS6KB1 (1.00) | RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015123174-A1 | PYRIMIDINE IMIDAZOLE AMINES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2015-08-20 | — | — | WO | disclosed |