Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 7/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE6D | O43924 | 1/20 | 0.46 |
| ▸ | PDE8A | O60658 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE9A | O76083 | 1/20 | 0.46 |
| ▸ | PDE8B | O95263 | 1/20 | 0.46 |
| ▸ | PDE6A | P16499 | 1/20 | 0.46 |
| ▸ | PDE6G | P18545 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE6B | P35913 | 1/20 | 0.46 |
| ▸ | PDE6C | P51160 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12071819 | 0.93 | CHRM3 (0.62) | CHRM3CHRNA7BCHEACHECHRM2 | |
| SCHEMBL1695975 | 0.93 | CHRM3 (0.62) | CHRM3CHRNA7BCHEACHECHRM2 | |
| SCHEMBL1695933 | 0.93 | CHRM3 (0.62) | CHRM3CHRNA7BCHEACHECHRM2 | |
| SCHEMBL1695935 | 0.93 | CHRM3 (0.62) | CHRM3CHRNA7BCHEACHECHRM2 | |
| SCHEMBL2486482 | 0.93 | CHRM3 (0.62) | CHRM3CHRNA7BCHEACHECHRM2 | |
| SCHEMBL13240861 | 0.89 | CHRNA7 (0.52) | CHRM3CHRNA7BCHEACHECHRM2 | |
| SCHEMBL2539062 | 0.89 | CHRNA7 (0.52) | CHRM3CHRNA7BCHEACHECHRM2 | |
| SCHEMBL1695691 | 0.88 | CHRM3 (0.57) | CHRM3CHRNA7BCHEACHECHRM2 | |
| SCHEMBL1701362 | 0.88 | CHRM3 (0.57) | CHRM3CHRNA7BCHEACHECHRM2 | |
| SCHEMBL1695689 | 0.88 | CHRM3 (0.57) | CHRM3CHRNA7BCHEACHECHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585459-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | Chiesi Farmaceutici S.p.A. (IT) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011161018-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-12-29 | — | — | WO | disclosed |