Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19010335 | 0.92 | FFAR1 (0.41) | FFAR1NTRK1CDK9EPHX2PPARG | |
| SCHEMBL17021356 | 0.91 | CDC7 (0.43) | FFAR1NTRK1EPHX2PPARGJAK3 | |
| SCHEMBL17021375 | 0.83 | JAK3 (0.44) | NTRK1CDK9JAK3CDC7ROCK2 | |
| SCHEMBL19010340 | 0.83 | FFAR1 (0.44) | FFAR1NTRK1CDK9KDM5AKDM4C | |
| SCHEMBL17021380 | 0.82 | FFAR1 (0.44) | FFAR1NTRK1KDM5AKDM4CKDM5B | |
| SCHEMBL19010334 | 0.81 | NTRK1 (0.42) | FFAR1NTRK1KDM5AKDM4CKDM5B | |
| SCHEMBL17021366 | 0.80 | JAK3 (0.44) | NTRK1JAK3CDC7ROCK2MAP4K4 | |
| SCHEMBL19010328 | 0.79 | FFAR1 (0.40) | FFAR1NTRK1KDM5AKDM4CKDM5B | |
| SCHEMBL17021433 | 0.79 | CD38 (0.41) | JAK3MET | |
| SCHEMBL17021385 | 0.78 | PTK2 (0.39) | FFAR1NTRK1KDM5AKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015123453-A1 | PYRIDAZINE COMPOUNDS AS JAK INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-08-20 | — | — | WO | disclosed |