Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561619 | 1.00 | GRM2 (0.63) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL4561618 | 1.00 | GRM2 (0.63) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL5019350 | 0.90 | GRM2 (0.58) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL4560523 | 0.90 | GRM2 (0.54) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL4561583 | 0.90 | GRM2 (0.54) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL4560522 | 0.90 | GRM2 (0.54) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL4561653 | 0.89 | GRM2 (0.73) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL4562065 | 0.89 | GRM2 (0.73) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL4561654 | 0.89 | GRM2 (0.73) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL10322385 | 0.84 | GRM2 (0.80) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649069-B1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2015-08-26 | — | — | EP | claimed |