SCHEMBL17023128

SCHEMBL17023128

COc1cc(OC)c(Cl)c(-c2ccc(OC(=O)Nc3nc(CN4CCOCC4)c[nH]3)c3nccnc23)c1Cl

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FGFR3 P22607 19/20 0.61
TP53 P04637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17023035 0.94 FGFR3 (0.52) FGFR3
SCHEMBL17023024 0.91 FGFR3 (0.59) FGFR3
SCHEMBL17023094 0.91 FGFR3 (0.59) FGFR3TP53
SCHEMBL17023051 0.91 FGFR3 (0.55) FGFR3
SCHEMBL1126286 0.90 FGFR3 (0.73) FGFR3
SCHEMBL17023091 0.88 FGFR3 (0.48) FGFR3
SCHEMBL17023049 0.86 FGFR3 (0.62) FGFR3
SCHEMBL17023077 0.85 FGFR3 (0.46) FGFR3
SCHEMBL17023131 0.85 FGFR3 (0.80) FGFR3
SCHEMBL17023114 0.85 FGFR3 (0.57) FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2282995-B1 DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS NOVARTIS AG (CH) 2015-08-26 EP claimed