SCHEMBL17023149

SCHEMBL17023149

COc1cc(OC)c(F)c(-c2ccc(OC(=O)Nc3ccc(CN4CCN(C)CC4)nc3)c3nccnc23)c1F

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FGFR3 P22607 19/20 0.58
MAPK7 Q13164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17023162 0.93 FGFR3 (0.55) FGFR3
SCHEMBL17023138 0.91 FGFR3 (0.67) FGFR3
SCHEMBL17023060 0.91 FGFR3 (0.59) FGFR3MAPK7
SCHEMBL1127019 0.89 FGFR3 (0.72) FGFR3
SCHEMBL17023157 0.88 FGFR3 (0.49) FGFR3
SCHEMBL17023115 0.85 FGFR3 (0.67) FGFR3
SCHEMBL17023076 0.85 FGFR3 (0.56) FGFR3
SCHEMBL17023167 0.84 FGFR3 (0.69) FGFR3
SCHEMBL17023084 0.84 FGFR3 (0.79) FGFR3
SCHEMBL17023178 0.83 FGFR3 (0.58) FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2282995-B1 DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS NOVARTIS AG (CH) 2015-08-26 EP claimed