Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 17/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17023022 | 0.87 | FGFR3 (0.77) | FGFR3NPC1RAB9ATP53 | |
| SCHEMBL1126100 | 0.86 | FGFR3 (0.78) | FGFR3NPC1RAB9AMITFTP53 | |
| SCHEMBL17023055 | 0.86 | FGFR3 (0.57) | FGFR3NPC1RAB9ATP53GAA | |
| SCHEMBL17023186 | 0.85 | FGFR3 (0.57) | FGFR3 | |
| SCHEMBL17023059 | 0.84 | FGFR3 (0.54) | FGFR3 | |
| SCHEMBL17023172 | 0.83 | FGFR3 (0.56) | FGFR3 | |
| SCHEMBL17023088 | 0.82 | FGFR3 (0.69) | FGFR3 | |
| SCHEMBL17023044 | 0.81 | FGFR3 (0.79) | FGFR3 | |
| SCHEMBL17023151 | 0.81 | FGFR3 (0.68) | FGFR3 | |
| SCHEMBL17023137 | 0.81 | FGFR3 (0.57) | FGFR3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |