SCHEMBL17028049

Cc1cc(C(F)(F)F)cnc1N[C@H]1CCCC1NC(=O)c1ncccc1-c1ncccn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	HCRTR1	O43613	20/20	1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL17007347	1.00	HCRTR1 (1.00)	HCRTR1
SCHEMBL17007241	0.91	HCRTR1 (1.00)	HCRTR1
SCHEMBL17028097	0.91	HCRTR1 (1.00)	HCRTR1
SCHEMBL17007207	0.90	HCRTR1 (1.00)	HCRTR1
SCHEMBL17007364	0.84	HCRTR1 (1.00)	HCRTR1
SCHEMBL17028128	0.84	HCRTR1 (1.00)	HCRTR1
SCHEMBL17028054	0.84	HCRTR1 (1.00)	HCRTR1
SCHEMBL17007306	0.84	HCRTR1 (1.00)	HCRTR1
SCHEMBL17017482	0.81	HCRTR1 (0.79)	HCRTR1
SCHEMBL17007205	0.81	HCRTR1 (1.00)	HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3107898-A1	1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS	Takeda Pharmaceutical Company Limited (JP)	2016-12-28	—	—	EP	claimed
WO-2015124932-A1	1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS	TAKEDA CAMBRIDGE LIMITED (GB)	2015-08-27	—	—	WO	claimed
EP-3107898-A1	1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS	Takeda Pharmaceutical Company Limited (JP)	2016-12-28	—	—	EP	disclosed
WO-2015124932-A1	1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS	TAKEDA CAMBRIDGE LIMITED (GB)	2015-08-27	—	—	WO	disclosed