Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 19/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17007122 | 1.00 | HCRTR1 (0.58) | HCRTR1HDAC4HDAC6HCRTR2 | |
| SCHEMBL22131260 | 0.90 | HCRTR1 (0.57) | HCRTR1HDAC4HDAC6HCRTR2 | |
| SCHEMBL17007392 | 0.90 | HCRTR1 (0.57) | HCRTR1HDAC4HDAC6HCRTR2 | |
| SCHEMBL17007268 | 0.89 | HCRTR1 (0.58) | HCRTR1 | |
| SCHEMBL22131257 | 0.89 | HCRTR1 (0.58) | HCRTR1 | |
| SCHEMBL17007180 | 0.89 | HCRTR1 (0.56) | HCRTR1HDAC4HDAC6HCRTR2 | |
| SCHEMBL17017351 | 0.87 | HCRTR1 (0.44) | HCRTR1HDAC4HDAC6 | |
| SCHEMBL17007191 | 0.86 | HCRTR1 (0.64) | HCRTR1 | |
| SCHEMBL17007313 | 0.81 | HCRTR1 (0.59) | HCRTR1HDAC4HDAC6HCRTR2 | |
| SCHEMBL17017349 | 0.81 | HCRTR1 (0.43) | HCRTR1HDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3107898-A1 | 1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2016-12-28 | — | — | EP | disclosed |
| WO-2015124932-A1 | 1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS | TAKEDA CAMBRIDGE LIMITED (GB) | 2015-08-27 | — | — | WO | disclosed |