SCHEMBL17029032

SCHEMBL17029032

Cc1cn2cc(-c3cccc(Cl)c3)nc2c(-c2cc(F)c3c(c2C)CCCO3)c1C(OC(C)(C)C)C(=O)O

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 2/20 0.57
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17039260 0.93 NR1I2 (0.50) NR1I2
SCHEMBL17029052 0.91 NR1I2 (0.57) NR1I2
SCHEMBL17029014 0.91 NR1I2 (0.58) NR1I2
SCHEMBL20344784 0.91 NR1I2 (0.57) NR1I2
SCHEMBL17039307 0.91 NR1I2 (0.58) NR1I2
SCHEMBL17029023 0.91 NR1I2 (0.58) NR1I2
SCHEMBL17029021 0.89 NR1I2 (0.45) NR1I2
SCHEMBL20344788 0.85 NR1I2 (0.42) NR1I2
SCHEMBL17039244 0.85 NR1I2 (0.42) NR1I2
SCHEMBL17029005 0.85 NR1I2 (0.42) NR1I2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3107913-A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION VIIV HEALTHCARE (NO.5) LIMITED (GB) 2016-12-28 EP disclosed
WO-2015126765-A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BRISTOL-MYERS SQUIBB COMPANY (US) 2015-08-27 WO disclosed