Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.47 |
| ▸ | RAB9A | P51151 | 10/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.47 |
| ▸ | RELA | Q04206 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5855563 | 0.87 | MEN1 (0.51) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL15491770 | 0.87 | MEN1 (0.41) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL15487557 | 0.86 | S1PR1 (0.43) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL17029096 | 0.85 | NPC1 (0.42) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL15593119 | 0.84 | NPC1 (0.47) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL17029094 | 0.81 | POLB (0.46) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL17029088 | 0.80 | MAPT (0.43) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL17029098 | 0.80 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL5857239 | 0.75 | PPARA (0.48) | NPC1RAB9AMAPK1TP53MEN1 | |
| SCHEMBL5857222 | 0.72 | KDR (0.57) | NPC1RAB9AMAPK1TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9115120-B2 | Heterocyclic modulators of HIF activity for treatment of disease | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMS (US) | 2015-08-25 | — | — | US | disclosed |