Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13778756 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A3ADRA1AHTR2BCYP2C19 | |
| SCHEMBL5019139 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A3ADRA1AHTR2BCYP2C19 | |
| SCHEMBL19668097 | 0.84 | SLC6A2 (0.47) | SLC6A2SLC6A3ADRA1AHTR2BCYP2C19 | |
| SCHEMBL19668081 | 0.84 | SLC6A2 (0.47) | SLC6A2SLC6A3ADRA1AHTR2BCYP2C19 | |
| SCHEMBL19668060 | 0.84 | SLC6A2 (0.47) | SLC6A2SLC6A3ADRA1AHTR2BCYP2C19 | |
| SCHEMBL23474171 | 0.77 | TSHR (0.52) | SLC6A2SLC6A3ADRA1AHTR2BCYP2C19 | |
| SCHEMBL4171081 | 0.76 | MAOB (0.48) | SLC6A2SLC6A3ADRA1AHTR2BCYP2C19 | |
| SCHEMBL4790557 | 0.76 | SMN1; SMN2 (0.46) | SLC6A2SLC6A3ADRA1AHTR2BCYP2C19 | |
| SCHEMBL4171085 | 0.76 | MAOB (0.48) | SLC6A2SLC6A3ADRA1AHTR2BCYP2C19 | |
| SCHEMBL4171082 | 0.76 | MAOB (0.48) | SLC6A2SLC6A3ADRA1AHTR2BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9271967-B2 | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2649069-B1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2015-08-26 | — | — | EP | disclosed |