Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.78 |
| ▸ | AKT2 | P31751 | 20/20 | 0.78 |
| ▸ | AKT3 | Q9Y243 | 20/20 | 0.78 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.73 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191257 | 1.00 | AKT1 (0.78) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191258 | 1.00 | AKT1 (0.78) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL22622567 | 0.95 | AKT1 (0.75) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL192278 | 0.91 | AKT1 (0.65) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL192277 | 0.91 | AKT1 (0.65) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191788 | 0.91 | AKT1 (0.85) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191789 | 0.91 | AKT1 (0.85) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191614 | 0.90 | AKT1 (0.73) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191615 | 0.90 | AKT1 (0.73) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL22149954 | 0.90 | AKT1 (0.86) | AKT1AKT2AKT3PIK3CAPRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399909-B1 | Hydroxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2015-08-26 | — | — | EP | disclosed |
| EP-2402325-B1 | Hydroxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2015-08-26 | — | — | EP | disclosed |