Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23505785 | 0.79 | NOTUM (0.49) | NOTUM | |
| SCHEMBL11119325 | 0.76 | NOTUM (0.47) | NOTUM | |
| SCHEMBL17348468 | 0.76 | NOTUM (0.47) | NOTUM | |
| SCHEMBL8363222 | 0.73 | HTR2A (0.36) | NOTUM | |
| SCHEMBL10748419 | 0.72 | NOTUM (0.47) | NOTUM | |
| SCHEMBL24127095 | 0.72 | NOTUM (0.44) | NOTUM | |
| SCHEMBL12407085 | 0.72 | NOTUM (0.44) | NOTUM | |
| SCHEMBL14403556 | 0.71 | CTNNB1 (0.46) | NOTUMAXLMERTK | |
| SCHEMBL12345221 | 0.71 | PARP1 (0.39) | — | |
| SCHEMBL17633587 | 0.71 | PARP1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2674428-B1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2016-04-06 | — | — | EP | disclosed |
| EP-2007756-B1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2015-08-26 | — | — | EP | disclosed |