⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172309 | 1.00 | — | — | |
| SCHEMBL162294 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL283015 | 0.98 | CYP2D6 (0.41) | — | |
| SCHEMBL28861034 | 0.98 | CYP2D6 (0.41) | — | |
| SCHEMBL28853863 | 0.98 | CYP2D6 (0.41) | — | |
| Hydrochloric Acid SCHEMBL191366 | 0.98 | CYP2D6 (0.41) | — | |
| Hydrochloric Acid SCHEMBL780213 | 0.98 | CYP2D6 (0.41) | — | |
| SCHEMBL4492257 | 0.98 | CYP2D6 (0.41) | — | |
| Hydrochloric Acid SCHEMBL28324857 | 0.98 | CYP2D6 (0.41) | — | |
| Hydrochloric Acid SCHEMBL26648780 | 0.98 | CYP2D6 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 340 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230175026-A1 | Process for the Preparation of a Chiral Piperazine-2-carboxylic Acid | HOFFMANN-LA ROCHE INC. (US) | 2023-06-08 | — | — | US | claimed |
| CN-115724801-A | Metal complex glass material with circular polarization luminescence characteristic and preparation method thereof | 北京师范大学 | 2023-03-03 | — | — | CN | claimed |
| CN-115461333-A | Process for the preparation of chiral piperazine-2-carboxylic acid | 豪夫迈·罗氏有限公司 | 2022-12-09 | — | — | CN | claimed |
| US-10017481-B2 | Conformationally constrained, fully synthetic macrocyclic compounds | POLYPHOR AG (CH) | 2018-07-10 | — | — | US | claimed |
| EP-2836485-B1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2018-01-10 | — | — | EP | claimed |
| CN-107051000-A | A kind of water proof material and its manufacture method and application | 徐州工程学院 | 2017-08-18 | — | — | CN | claimed |
| US-20150051183-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2015-02-19 | — | — | US | claimed |
| EP-2836485-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | Polyphor Ag (CH) | 2015-02-18 | — | — | EP | claimed |
| WO-2013139697-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2013-09-26 | — | — | WO | claimed |
| US-12637702-B2 | Process for preparing substituted imidazo[1,5-α]pyrazines | HOFFMANN-LA ROCHE INC. (US) | 2026-05-26 | — | — | US | disclosed |
| EP-4463455-B1 | HETEROALICYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SUVEN LIFE SCIENCES LTD (IN) | 2026-04-29 | — | — | EP | disclosed |
| US-12544448-B2 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors | Revolution Medicines, Inc. (US) | 2026-02-10 | — | — | US | disclosed |
| US-12391698-B2 | Substituted piperidines and piperazines and methods for the treatment of CNS disorders | SUVEN LIFE SCIENCES LIMITED (IN) | 2025-08-19 | — | — | US | disclosed |
| US-12351575-B2 | 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2025-07-08 | — | — | US | disclosed |
| EP-0617968-A1 | HIV protease inhibitors in pharmaceutical combinant for the treatment of AIDS | MERCK & CO. INC. (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5348955-A | Angiotensis II antagonists | MERCK & CO., INC. (US) | 1994-09-20 | — | — | US | disclosed |
| WO-1994018192-A1 | PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| WO-1994013646-A1 | N,N-DIACYLPIPERAZINE TACHYKININ ANTAGONISTS | MERCK & CO., INC. (US) | 1994-06-23 | — | — | WO | disclosed |
| WO-1993009096-A1 | HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS | MERCK & CO., INC. (US) | 1993-05-13 | — | — | WO | disclosed |
| WO-1992020661-A1 | N, N-DIACYLPIPERAZINES | MERCK & CO., INC. (US) | 1992-11-26 | — | — | WO | disclosed |