Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.40 |
| ▸ | SPIN4 | Q56A73 | 1/20 | 0.40 |
| ▸ | SPIN3 | Q5JUX0 | 1/20 | 0.40 |
| ▸ | SPIN2B | Q9BPZ2 | 1/20 | 0.40 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.40 |
| ▸ | KRAS | P01116 | 2/20 | 0.40 |
| ▸ | NMT2 | O60551 | 2/20 | 0.37 |
| ▸ | NMT1 | P30419 | 2/20 | 0.37 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19695805 | 0.90 | KRAS (0.39) | SPIN4SPIN3SPIN2BSPIN1KRAS | |
| SCHEMBL19681378 | 0.87 | KRAS (0.47) | SPIN4SPIN3SPIN2BSPIN1KRAS | |
| SCHEMBL16637082 | 0.83 | KRAS (0.45) | KRASNMT2NMT1EHMT2 | |
| SCHEMBL18133917 | 0.81 | SLC29A1 (0.36) | SLC29A1KRASMRGPRX1MEN1KMT2A | |
| SCHEMBL16637080 | 0.79 | KRAS (0.39) | KRASNMT2NMT1MRGPRX1CSNK2A1 | |
| SCHEMBL17030870 | 0.77 | KRAS (0.55) | KRAS | |
| SCHEMBL17030874 | 0.77 | SMN1; SMN2 (0.44) | MEN1KMT2A | |
| SCHEMBL27147161 | 0.77 | SMN1; SMN2 (0.44) | MEN1KMT2A | |
| SCHEMBL18133913 | 0.76 | KRAS (0.48) | KRASEHMT2 | |
| SCHEMBL18133893 | 0.73 | TLR7 (0.46) | KRASNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2018-05-03 | — | — | US | disclosed |
| US-9840516-B2 | Substituted quinazolines as inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2017-12-12 | — | — | US | disclosed |
| US-20150239900-A1 | INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118757-A1 | SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | SLC29A1 2712/4885SPIN4 2092/4885SPIN3 1471/4885 |
| US-20150239900-A1 | INHIBITORS OF KRAS G12C | KRAS, NRAS, HRAS | SLC29A1 2856/4885SPIN4 1894/4885SPIN3 1453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.