⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24198438 | 0.77 | — | — | |
| SCHEMBL27947164 | 0.77 | — | — | |
| SCHEMBL27721021 | 0.77 | ERN1 (0.33) | — | |
| SCHEMBL15960866 | 0.76 | EGFR (0.34) | — | |
| SCHEMBL9131053 | 0.74 | ERN1 (0.36) | — | |
| SCHEMBL25926334 | 0.74 | EGFR (0.33) | — | |
| SCHEMBL3700433 | 0.73 | — | — | |
| SCHEMBL6338655 | 0.73 | — | — | |
| SCHEMBL29955751 | 0.73 | — | — | |
| SCHEMBL28146377 | 0.72 | RET (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0704429-B1 | 2-(Aryliminomethyl)-3-(disubstituted amino)acrylonitriles, a process for their preparation and their use | BAYER AG (DE) | 1998-06-10 | — | — | EP | claimed |
| EP-0704429-A1 | 2-(Aryliminomethyl)-3-(disubstituted amino)acrylonitriles, a process for their preparation and their use | BAYER AG (DE) | 1996-04-03 | — | — | EP | claimed |
| US-12617801-B2 | Tetrahydrothieno pyridine derivatives as DDRS inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2026-05-05 | — | — | US | disclosed |
| EP-4594318-A1 | AKT1 MODULATORS | Alterome Therapeutics, Inc. (US) | 2025-08-06 | — | — | EP | disclosed |
| EP-4587014-A2 | C5AR1 ANTAGONISTS AND USES THEREOF | Vanqua Bio, Inc. (US) | 2025-07-23 | — | — | EP | disclosed |
| US-20250092040-A1 | AKT1 MODULATORS | ALTEROME THERAPEUTICS, INC. | 2025-03-20 | — | — | US | disclosed |
| EP-4313994-B1 | TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARM SPA (IT) | 2025-03-05 | — | — | EP | disclosed |
| CN-116332859-B | Hydrazone compound and preparation method and application thereof | 华中师范大学 | 2025-02-25 | — | — | CN | disclosed |
| US-20240383915-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2024-11-21 | — | — | US | disclosed |
| US-20240239797-A1 | AKT1 MODULATORS | ALTEROME THERAPEUTICS, INC. | 2024-07-18 | — | — | US | disclosed |
| US-20240199635-A1 | TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-06-20 | — | — | US | disclosed |
| US-5030728-A | Cyclic compounds for forming complexes with urea, guanidine and amidine derivatives | THE RESEARCH FOUNDATION STATE UNIVERSITY OF NEW YORK (US) | 1991-07-09 | — | — | US | disclosed |
| CN-1048706-A | 3-substituted vinyl cephalosporin derivatives and preparation method thereof | EISAI CO LTD (JP) | 1991-01-23 | — | — | CN | disclosed |
| EP-0408034-A1 | 3-Substituted vinyl cephalosporin derivatives | Eisai Co., Ltd. (JP) | 1991-01-16 | — | — | EP | disclosed |
| EP-0103126-B1 | PROCESS FOR PREPARING 4-AMINO-5-DIALKOXYMETHYLPYRIMIDINE DERIVATIVES | UBE INDUSTRIES, LTD. (JP) | 1987-03-04 | — | — | EP | disclosed |
| US-4492792-A | Process for preparing 4-amino-5-dialkoxy-methylpyrimidine derivatives | UBE INDUSTRIES, LTD. (JP) | 1985-01-08 | — | — | US | disclosed |
| EP-0103126-A1 | Process for preparing 4-amino-5-dialkoxymethylpyrimidine derivatives | UBE INDUSTRIES, LTD. (JP) | 1984-03-21 | — | — | EP | disclosed |
| EP-0018151-B1 | 6-SUBSTITUTED-ARYLPYRIDO(2,3-D)PYRIMIDIN-7-AMINES, DERIVATIVES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING ANY OF THE FOREGOING, AND PROCESSES FOR PRODUCING ANY OF THE FOREGOING | WARNER-LAMBERT COMPANY (US) | 1984-01-25 | — | — | EP | disclosed |
| US-4271164-A | HYPOTENSIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1981-06-02 | — | — | US | disclosed |
| EP-0018151-A1 | 6-Substituted-arylpyrido(2,3-d)pyrimidin-7-amines, derivatives and salts thereof, pharmaceutical compositions containing any of the foregoing, and processes for producing any of the foregoing | WARNER-LAMBERT COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |