Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNKP | Q96T60 | 20/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22683134 | 0.87 | PNKP (1.00) | PNKP | |
| SCHEMBL17603648 | 0.87 | PNKP (1.00) | PNKP | |
| SCHEMBL22683117 | 0.87 | PNKP (1.00) | PNKP | |
| SCHEMBL22000586 | 0.83 | PNKP (0.74) | PNKP | |
| SCHEMBL22683120 | 0.82 | PNKP (1.00) | PNKP | |
| SCHEMBL1703545 | 0.82 | PNKP (1.00) | PNKP | |
| SCHEMBL20512281 | 0.82 | PNKP (1.00) | PNKP | |
| SCHEMBL22000575 | 0.82 | PNKP (1.00) | PNKP | |
| SCHEMBL17019712 | 0.82 | PNKP (1.00) | PNKP | |
| SCHEMBL22000257 | 0.82 | PNKP (1.00) | PNKP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635579-B1 | SYNTHETIC LETHALITY IN CANCER | UNIV ALBERTA (CA) | 2020-11-25 | — | — | EP | claimed |
| US-10087448-B2 | Synthetic lethality in cancer | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2018-10-02 | — | — | US | claimed |
| US-9694073-B2 | Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2017-07-04 | — | — | US | claimed |
| US-20160083732-A1 | SYNTHETIC LETHALITY IN CANCER | ALBERTA HEALTH SERVICES (CA) | 2016-03-24 | — | — | US | claimed |
| US-20150306219-A1 | SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE, POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF | ALBERTA HEALTH SERVICES (CA) | 2015-10-29 | — | — | US | claimed |
| US-9040551-B2 | Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2015-05-26 | — | — | US | claimed |
| US-20130289095-A1 | SYNTHETIC LETHALITY IN CANCER | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2013-10-31 | — | — | US | claimed |
| US-20120142721-A1 | SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE, POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF | ALBERTA HEALTH SERVICES (CA) | 2012-06-07 | — | — | US | claimed |
| EP-2635579-B1 | SYNTHETIC LETHALITY IN CANCER | UNIV ALBERTA (CA) | 2020-11-25 | — | — | EP | disclosed |
| US-10087448-B2 | Synthetic lethality in cancer | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2018-10-02 | — | — | US | disclosed |
| US-9694073-B2 | Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2017-07-04 | — | — | US | disclosed |
| US-20160083732-A1 | SYNTHETIC LETHALITY IN CANCER | ALBERTA HEALTH SERVICES (CA) | 2016-03-24 | — | — | US | disclosed |
| US-20150306219-A1 | SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE, POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF | ALBERTA HEALTH SERVICES (CA) | 2015-10-29 | — | — | US | disclosed |
| US-9115406-B2 | Synthetic lethality in cancer | THE GOVENORS OF THE UNIVERSITY OF ALBERTA (CA) | 2015-08-25 | — | — | US | disclosed |
| US-9040551-B2 | Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2015-05-26 | — | — | US | disclosed |
| US-20130289095-A1 | SYNTHETIC LETHALITY IN CANCER | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2013-10-31 | — | — | US | disclosed |
| US-20120142721-A1 | SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE, POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF | ALBERTA HEALTH SERVICES (CA) | 2012-06-07 | — | — | US | disclosed |
| EP-2440203-A1 | SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE. POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF | The Governors Of The University Of Alberta (CA) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010139069-A1 | SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE. POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2010-12-09 | — | — | WO | disclosed |