Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.82 |
| ▸ | AURKB | Q96GD4 | 20/20 | 0.82 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.62 |
| ▸ | WEE1 | P30291 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | SYK | P43405 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3771185 | 1.00 | KDR (0.82) | KDRAURKBAURKALCKPDGFRA | |
| SCHEMBL3773569 | 1.00 | KDR (0.82) | KDRAURKBAURKALCKPDGFRA | |
| SCHEMBL3780278 | 0.93 | KDR (0.82) | KDRAURKBAURKALCKPDGFRA | |
| SCHEMBL3771703 | 0.93 | KDR (0.82) | KDRAURKBAURKALCKPDGFRA | |
| SCHEMBL3777798 | 0.90 | KDR (1.00) | KDRAURKBAURKALCKPDGFRA | |
| SCHEMBL3780161 | 0.89 | KDR (1.00) | KDRAURKBAURKALCKPDGFRA | |
| SCHEMBL3772320 | 0.89 | KDR (1.00) | KDRAURKBAURKALCKPDGFRA | |
| SCHEMBL3784712 | 0.89 | KDR (1.00) | KDRAURKBAURKALCKPDGFRA | |
| SCHEMBL3777790 | 0.89 | KDR (1.00) | KDRAURKBAURKALCKPDGFRA | |
| SCHEMBL1703186 | 0.89 | KDR (0.83) | KDRAURKBAURKALCKPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440548-A1 | 2- ( LH-PYRAZOL-4 -YLAMINO ) -PYRIMIDINE AS KINASE INHIBITORS | Abbott Laboratories (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144468-A1 | 2- ( LH-PYRAZOL-4 -YLAMINO ) -PYRIMIDINE AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2010-12-16 | — | — | WO | disclosed |