SCHEMBL1703786

SCHEMBL1703786

Cc1ccc2c(c1)nc(N)c1ncc(C#Cc3ccc(CCC(=O)O)cc3)cc12

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 15/20 0.52
TLR7 Q9NYK1 5/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1063023 0.90 TLR7 (0.45) FFAR1TLR7
SCHEMBL1062178 0.87 TLR7 (0.59) TLR7
SCHEMBL2364782 0.87 TLR7 (0.42) TLR7
SCHEMBL1008090 0.84 TLR7 (0.43) TLR7
SCHEMBL2364785 0.83 FFAR1 (0.46) FFAR1TLR7
SCHEMBL1675523 0.82 TLR7 (0.44) TLR7
SCHEMBL1059582 0.80 TLR7 (0.43) TLR7
SCHEMBL1007752 0.79 TLR7 (0.47) TLR7
SCHEMBL1060970 0.79 TLR7 (0.63) TLR7
SCHEMBL1062584 0.79 TLR7 (0.70) TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2440245-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES Novartis AG (CH) 2012-04-18 EP disclosed
WO-2010144734-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES NOVARTIS AG (CH) 2010-12-16 WO disclosed