Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 20/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313152 | 0.85 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL4305751 | 0.81 | SLC6A4 (0.69) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL4308682 | 0.80 | SLC6A4 (0.64) | SLC6A4SLC6A3SLC6A2HRH3 | |
| SCHEMBL17044152 | 0.80 | SLC6A4 (0.58) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL4303606 | 0.80 | SLC6A4 (0.69) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL4312426 | 0.80 | SLC6A4 (0.66) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL4306331 | 0.80 | SLC6A4 (0.66) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL4308404 | 0.79 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2HRH3 | |
| SCHEMBL4309477 | 0.79 | SLC6A4 (0.61) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL4303961 | 0.77 | SLC6A2 (0.74) | SLC6A4SLC6A3SLC6A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778639-B1 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | ALBANY MOLECULAR RES INC (US) | 2015-09-02 | — | — | EP | disclosed |