Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.68 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | BCL2 | P10415 | 6/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.47 |
| ▸ | BAD | Q92934 | 3/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | EEF2K | O00418 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17044275 | 0.91 | MCL1 (0.66) | MCL1PIN1BCL2BCL2L1BAD | |
| SCHEMBL17044267 | 0.91 | MCL1 (0.66) | MCL1BCL2BCL2L1BADALB | |
| SCHEMBL17044365 | 0.89 | MCL1 (0.65) | MCL1PIN1BCL2BCL2L1BAD | |
| SCHEMBL2204297 | 0.87 | MCL1 (0.88) | MCL1PIN1FOLH1BCL2BCL2L1 | |
| SCHEMBL17044357 | 0.86 | MCL1 (0.64) | MCL1PIN1BCL2BCL2L1BAD | |
| SCHEMBL17044249 | 0.86 | MCL1 (0.64) | MCL1BCL2BCL2L1BADALB | |
| SCHEMBL19180450 | 0.86 | MCL1 (0.57) | MCL1PIN1BCL2BADALB | |
| SCHEMBL17044363 | 0.84 | MCL1 (0.58) | MCL1BCL2BCL2L1BADALB | |
| SCHEMBL17044270 | 0.83 | MCL1 (0.57) | MCL1PIN1BCL2BCL2L1BAD | |
| SCHEMBL17044326 | 0.82 | MCL1 (0.56) | MCL1PIN1BCL2BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134685-B1 | 7-NONSUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2015-09-02 | — | — | EP | claimed |