Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.50 |
| ▸ | MARK3 | P27448 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.50 |
| ▸ | NEK4 | P51957 | 2/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.50 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.50 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.50 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.50 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.50 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.50 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.50 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.50 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.50 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.50 |
| ▸ | EEF2K | O00418 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17044345 | 0.97 | MARK3 (0.53) | CDC7MARK3GSK3BIRAK1NEK4 | |
| SCHEMBL17044348 | 0.95 | XBP1 (0.50) | CDC7MARK3GSK3BIRAK1NEK4 | |
| SCHEMBL2204966 | 0.87 | MARK3 (0.66) | CDC7MARK3GSK3BIRAK1NEK4 | |
| SCHEMBL17044251 | 0.86 | MARK3 (0.55) | CDC7MARK3GSK3BIRAK1NEK4 | |
| SCHEMBL2202627 | 0.84 | MARK3 (0.70) | CDC7MARK3GSK3BIRAK1NEK4 | |
| SCHEMBL17044304 | 0.83 | MARK3 (0.71) | CDC7MARK3GSK3BIRAK1NEK4 | |
| SCHEMBL2206467 | 0.83 | CDC7 (0.54) | CDC7MARK3GSK3BIRAK1NEK4 | |
| SCHEMBL17044374 | 0.82 | MARK3 (0.62) | CDC7MARK3GSK3BIRAK1NEK4 | |
| SCHEMBL2204657 | 0.81 | MARK3 (0.63) | CDC7MARK3GSK3BIRAK1NEK4 | |
| SCHEMBL17044246 | 0.81 | MARK3 (0.52) | CDC7MARK3GSK3BIRAK1NEK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134685-B1 | 7-NONSUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2015-09-02 | — | — | EP | claimed |