Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 9/20 | 0.37 |
| ▸ | RXRB | P28702 | 9/20 | 0.37 |
| ▸ | RXRG | P48443 | 6/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | EEF2K | O00418 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | NEK4 | P51957 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2207369 | 0.89 | MARK3 (0.49) | MCL1L3MBTL1RXRARXRBRXRG | |
| SCHEMBL17044342 | 0.86 | MARK3 (0.49) | MCL1L3MBTL1CDC7EEF2KDAPK3 | |
| SCHEMBL17044388 | 0.81 | MARK3 (0.56) | MCL1RXRARXRBRXRGCDC7 | |
| SCHEMBL17044308 | 0.79 | MARK3 (0.50) | MCL1L3MBTL1CDC7EEF2KDAPK3 | |
| SCHEMBL17044271 | 0.77 | MARK3 (0.49) | MCL1CDC7EEF2KDAPK3MAP4K4 | |
| SCHEMBL17044355 | 0.77 | MARK3 (0.49) | MCL1CDC7EEF2KDAPK3MAP4K4 | |
| SCHEMBL17044334 | 0.77 | MARK3 (0.58) | MCL1L3MBTL1CDC7EEF2KDAPK3 | |
| SCHEMBL17044351 | 0.76 | MARK3 (0.46) | MCL1CDC7EEF2KDAPK3MAP4K4 | |
| SCHEMBL2205072 | 0.74 | MARK3 (0.65) | MCL1CDC7EEF2KDAPK3MAP4K4 | |
| SCHEMBL2207188 | 0.70 | MARK3 (0.54) | MCL1CDC7EEF2KDAPK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134685-B1 | 7-NONSUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2015-09-02 | — | — | EP | claimed |