Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 15/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | EEF2K | O00418 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206133 | 0.88 | CDC7 (0.59) | LMNAMAPTNPC1POLBHPGD | |
| SCHEMBL17044301 | 0.85 | MARK3 (0.58) | MCL1CDC7EEF2KDAPK3MAP4K4 | |
| SCHEMBL17044287 | 0.83 | MARK3 (0.57) | MCL1CDC7EEF2KDAPK3MAP4K4 | |
| SCHEMBL17044236 | 0.83 | MCL1 (0.54) | MCL1CDC7EEF2KDAPK3MAP4K4 | |
| SCHEMBL17044279 | 0.81 | MARK3 (0.48) | HPGDMCL1CDC7EEF2KDAPK3 | |
| SCHEMBL17044325 | 0.80 | MCL1 (0.56) | MCL1CDC7EEF2KDAPK3MAP4K4 | |
| SCHEMBL17044378 | 0.80 | MARK3 (0.58) | MCL1CDC7EEF2KDAPK3MAP4K4 | |
| SCHEMBL17044226 | 0.80 | MARK3 (0.58) | MCL1CDC7EEF2KDAPK3MAP4K4 | |
| SCHEMBL17044335 | 0.80 | CDC7 (0.45) | LMNAMAPTSMN1; SMN2CNR2MCL1 | |
| SCHEMBL17044216 | 0.80 | MARK3 (0.60) | MCL1CDC7EEF2KDAPK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134685-B1 | 7-NONSUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2015-09-02 | — | — | EP | claimed |