Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 4/20 | 0.55 |
| ▸ | CAMK2B | Q13554 | 4/20 | 0.55 |
| ▸ | MARK2 | Q7KZI7 | 4/20 | 0.55 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.55 |
| ▸ | NEK4 | P51957 | 3/20 | 0.55 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.55 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.55 |
| ▸ | EEF2K | O00418 | 2/20 | 0.55 |
| ▸ | AXL | P30530 | 2/20 | 0.55 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.55 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 2/20 | 0.55 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.55 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.55 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.55 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17044350 | 0.92 | MCL1 (0.50) | MARK3CAMK2BMARK2HIPK2NEK4 | |
| SCHEMBL2203854 | 0.87 | MARK3 (0.70) | MARK3CAMK2BMARK2HIPK2NEK4 | |
| SCHEMBL17044344 | 0.87 | MARK3 (0.66) | MARK3CAMK2BMARK2HIPK2NEK4 | |
| SCHEMBL17044377 | 0.84 | MCL1 (0.57) | MARK3CAMK2BMARK2HIPK2NEK4 | |
| SCHEMBL17044301 | 0.83 | MARK3 (0.58) | MARK3CAMK2BMARK2HIPK2NEK4 | |
| SCHEMBL17044255 | 0.83 | MARK3 (0.75) | MARK3CAMK2BMARK2HIPK2NEK4 | |
| SCHEMBL17044303 | 0.83 | MARK3 (0.63) | MARK3CAMK2BMARK2HIPK2NEK4 | |
| SCHEMBL17044226 | 0.82 | MARK3 (0.58) | MARK3CAMK2BMARK2HIPK2NEK4 | |
| SCHEMBL17044287 | 0.81 | MARK3 (0.57) | MARK3CAMK2BMARK2HIPK2NEK4 | |
| SCHEMBL17044290 | 0.81 | MARK3 (0.67) | MARK3CAMK2BMARK2HIPK2NEK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134685-B1 | 7-NONSUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2015-09-02 | — | — | EP | claimed |