Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 20/20 | 0.71 |
| ▸ | BCL2 | P10415 | 4/20 | 0.71 |
| ▸ | ALB | P02768 | 1/20 | 0.71 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.57 |
| ▸ | BAD | Q92934 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17044356 | 0.88 | MCL1 (0.58) | MCL1BCL2ALBBCL2L1BAD | |
| SCHEMBL17044339 | 0.88 | MCL1 (0.57) | MCL1BCL2ALBBCL2L1BAD | |
| SCHEMBL17044340 | 0.88 | MCL1 (0.56) | MCL1BCL2ALBBCL2L1BAD | |
| SCHEMBL17044250 | 0.87 | MCL1 (0.54) | MCL1BCL2ALBBCL2L1 | |
| SCHEMBL17044310 | 0.87 | MCL1 (0.56) | MCL1BCL2ALBBCL2L1BAD | |
| SCHEMBL17044370 | 0.87 | MCL1 (0.55) | MCL1BCL2ALBBCL2L1BAD | |
| SCHEMBL19179104 | 0.86 | MCL1 (0.67) | MCL1BCL2ALBBCL2L1BAD | |
| SCHEMBL17044318 | 0.86 | MCL1 (0.56) | MCL1BCL2ALBBCL2L1BAD | |
| SCHEMBL17044364 | 0.86 | MCL1 (0.54) | MCL1BCL2ALBBCL2L1BAD | |
| SCHEMBL19178643 | 0.85 | MCL1 (0.56) | MCL1BCL2ALBBCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134685-B1 | 7-NONSUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2015-09-02 | — | — | EP | claimed |