Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FSHR | P23945 | 9/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3160570 | 1.00 | FSHR (0.41) | FSHRMMP1MMP2MMP9TSHR | |
| SCHEMBL2388862 | 1.00 | FSHR (0.41) | FSHRMMP1MMP2MMP9TSHR | |
| SCHEMBL11973791 | 0.91 | FSHR (0.41) | FSHRMMP1MMP2MMP9TSHR | |
| SCHEMBL11973331 | 0.91 | FSHR (0.41) | FSHRMMP1MMP2MMP9TSHR | |
| SCHEMBL17054382 | 0.90 | FSHR (0.40) | FSHRMMP1MMP2MMP9TSHR | |
| SCHEMBL8988202 | 0.89 | FSHR (0.44) | FSHRMMP1MMP2MMP9TSHR | |
| SCHEMBL11973796 | 0.89 | TP53 (0.38) | TSHR | |
| SCHEMBL2389637 | 0.89 | FSHR (0.44) | FSHRMMP1MMP2MMP9TSHR | |
| SCHEMBL2392497 | 0.89 | FSHR (0.44) | FSHRMMP1MMP2MMP9TSHR | |
| SCHEMBL2392758 | 0.89 | FSHR (0.41) | FSHRMMP1MMP2MMP9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2294069-B1 | THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO[3,2,1-IJ]QUINOLINE COMPOUNDS | ALLERGAN INC (US) | 2015-09-02 | — | — | EP | disclosed |