Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 11/20 | 0.45 |
| ▸ | BAD | Q92934 | 3/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | MARK3 | P27448 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.43 |
| ▸ | NEK4 | P51957 | 2/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.43 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.43 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.43 |
| ▸ | EEF2K | O00418 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202279 | 0.90 | MARK3 (0.55) | MCL1BADBCL2L1CDC7MARK3 | |
| SCHEMBL17044272 | 0.86 | MARK3 (0.47) | MCL1BADBCL2L1CDC7MARK3 | |
| SCHEMBL17044248 | 0.84 | MARK3 (0.49) | MCL1BADBCL2L1CDC7MARK3 | |
| SCHEMBL17044369 | 0.81 | MARK3 (0.44) | MCL1BADBCL2L1CDC7MARK3 | |
| SCHEMBL17044325 | 0.81 | MCL1 (0.56) | MCL1BADBCL2L1CDC7MARK3 | |
| SCHEMBL17044218 | 0.81 | MARK3 (0.52) | MCL1BADBCL2L1CDC7MARK3 | |
| SCHEMBL17044343 | 0.81 | MARK3 (0.64) | MCL1BADCDC7MARK3GSK3B | |
| SCHEMBL17044366 | 0.79 | MARK3 (0.50) | MCL1BADBCL2L1CDC7MARK3 | |
| SCHEMBL17044308 | 0.79 | MARK3 (0.50) | MCL1BADBCL2L1CDC7MARK3 | |
| SCHEMBL17044312 | 0.78 | MARK3 (0.56) | MCL1BADCDC7MARK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134685-B1 | 7-NONSUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2015-09-02 | — | — | EP | claimed |