SCHEMBL1704485

SCHEMBL1704485

CC1CN(Cc2ccc(CC(=O)N3CCC(Nc4cccc(C#N)c4)CC3)cc2)CCN1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MLNR O43193 20/20 1.00
CYP3A4 P08684 6/20 1.00
CYP2D6 P10635 1/20 0.78
KCNH2 Q12809 1/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1704116 1.00 MLNR (1.00) MLNRCYP3A4CYP2D6KCNH2
SCHEMBL1704483 1.00 MLNR (1.00) MLNRCYP3A4CYP2D6KCNH2
SCHEMBL1704096 0.89 MLNR (1.00) MLNRCYP3A4CYP2D6KCNH2
SCHEMBL1704626 0.89 MLNR (1.00) MLNRCYP3A4CYP2D6KCNH2
Camicinal SCHEMBL1704099 0.88 MLNR (1.00) MLNRCYP3A4CYP2D6KCNH2
Camicinal SCHEMBL1703910 0.88 MLNR (1.00) MLNRCYP3A4CYP2D6KCNH2
SCHEMBL377929 0.87 MLNR (0.77) MLNRCYP3A4CYP2D6KCNH2
SCHEMBL11967629 0.86 MLNR (0.82) MLNRCYP3A4CYP2D6KCNH2
SCHEMBL1704416 0.86 MLNR (0.82) MLNRCYP3A4CYP2D6KCNH2
SCHEMBL1704164 0.85 MLNR (1.00) MLNRCYP3A4CYP2D6KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2441763-A1 Benzylpiperazine derivatives useful for the treatment of gastrointestinal disorders Glaxo Group Limited (GB) 2012-04-18 EP disclosed