Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GUSB | P08236 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17047556 | 0.87 | KDR (0.38) | PIK3CAPIK3CGMAP3K5PIK3CDMAPT | |
| SCHEMBL17047445 | 0.84 | MAP3K5 (0.58) | MAP3K5BRAFPDE10ANPC1SMN1; SMN2 | |
| SCHEMBL17047546 | 0.83 | ACP1 (0.39) | PIK3CAPIK3CGMAP3K5BRAFPIK3CD | |
| SCHEMBL17047489 | 0.83 | PIK3CG (0.42) | PIK3CAPIK3CGMAP3K5PIK3CDMAPT | |
| SCHEMBL17047468 | 0.82 | PIK3CA (0.43) | PIK3CAPIK3CGMAP3K5PIK3CDTNF | |
| SCHEMBL17047465 | 0.81 | MAP3K5 (0.38) | PIK3CAPIK3CGMAP3K5PDE10APIK3CD | |
| SCHEMBL17047434 | 0.79 | MAP3K5 (0.36) | PIK3CAPIK3CGMAP3K5BRAFPDE10A | |
| SCHEMBL17047442 | 0.78 | CYP1A2 (0.50) | PIK3CAPIK3CGNPC1MAPTCCNA2 | |
| SCHEMBL17047530 | 0.76 | CDK1 (0.39) | PIK3CAPIK3CGMAP3K5BRAFPDE10A | |
| SCHEMBL17047471 | 0.76 | KDM4E (0.39) | PIK3CAPIK3CGMAP3K5PDE10APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202374-B2 | 6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2019-02-12 | — | — | US | disclosed |
| EP-3110801-B1 | 6-ARYL-4-PHENYLAMINO-QUINAZOLINE ANALOGS AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS | COUNCIL SCIENT IND RES (IN) | 2019-01-30 | — | — | EP | disclosed |
| US-20170015662-A1 | 6-ARYL-4-PHENYLAMINO-QUINAZOLINE ANALOGS AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-01-19 | — | — | US | disclosed |
| EP-3110801-A1 | 6-ARYL-4-PHENYLAMINO-QUINAZOLINE ANALOGS AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-01-04 | — | — | EP | disclosed |
| WO-2015128873-A1 | \"6-ARYL-4-PHENYLAMINO-QUINAZOLINE ANALOGS AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS\ | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202374-B2 | 6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors | PIK3CA, PI4KA, PDPK1 | PIK3CA 1/4885PIK3CG 5/4885MAP3K5 33/4885 |
| US-20170015662-A1 | 6-ARYL-4-PHENYLAMINO-QUINAZOLINE ANALOGS AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS | PIK3CA, PI4KA, PDPK1 | PIK3CA 1/4885PIK3CG 5/4885MAP3K5 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.