Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.95 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.65 |
| ▸ | INSR | P06213 | 1/20 | 0.65 |
| ▸ | INSRR | P14616 | 1/20 | 0.65 |
| ▸ | LTK | P29376 | 1/20 | 0.65 |
| ▸ | CLK1 | P49759 | 1/20 | 0.65 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.65 |
| ▸ | MERTK | Q12866 | 1/20 | 0.65 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17048359 | 0.98 | ALK (1.00) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL17048283 | 0.91 | ALK (1.00) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL17048257 | 0.89 | ALK (0.96) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL18589044 | 0.87 | ALK (0.82) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL17048124 | 0.87 | ALK (1.00) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL17048256 | 0.87 | ALK (1.00) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL20182828 | 0.86 | ALK (0.83) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL17048388 | 0.86 | ALK (1.00) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL17054322 | 0.86 | ALK (0.80) | ALKDAPK3INSRINSRRLTK | |
| SCHEMBL18589151 | 0.85 | ALK (0.78) | ALKDAPK3INSRINSRRLTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3110815-A1 | INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS | Jiangsu Ascentage Biomed Development Inc. (CN) | 2017-01-04 | — | — | EP | disclosed |
| WO-2015127629-A1 | INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS | JIANGSU ASCENTAGE BIOMED DEVELOPMENT INC. (CN) | 2015-09-03 | — | — | WO | disclosed |