Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 4/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704941 | 1.00 | BTK (0.49) | BTKSYKEGFRLCKJAK3 | |
| SCHEMBL1705199 | 0.89 | BTK (0.49) | BTKSYKEGFRLCKJAK3 | |
| SCHEMBL1705612 | 0.88 | BTK (0.52) | BTKSYKEGFRLCKJAK3 | |
| SCHEMBL16798536 | 0.87 | BTK (0.56) | BTKSYKEGFRLCKJAK3 | |
| SCHEMBL16798535 | 0.87 | BTK (0.56) | BTKSYKEGFRLCKJAK3 | |
| SCHEMBL1705889 | 0.85 | BTK (0.44) | BTKSYKEGFRLCKJAK3 | |
| SCHEMBL16798395 | 0.85 | EGFR (0.58) | BTKEGFRLCKJAK3 | |
| SCHEMBL16798397 | 0.85 | EGFR (0.58) | BTKEGFRLCKJAK3 | |
| SCHEMBL16798481 | 0.81 | BTK (0.44) | BTKEGFRLCKJAK3JAK2 | |
| SCHEMBL16798480 | 0.81 | BTK (0.44) | BTKEGFRLCKJAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440204-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | Bristol-Myers Squibb Company (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144647-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-16 | — | — | WO | disclosed |