Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.54 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.54 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.54 |
| ▸ | IL2 | P60568 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12155799 | 0.89 | STIM1 (0.69) | STIM1ORAI1ORAI2IL2ABL1 | |
| SCHEMBL12155661 | 0.81 | STIM1 (0.57) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL12155789 | 0.80 | STIM1 (0.66) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL12155796 | 0.79 | IL2 (0.58) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL12156046 | 0.79 | STIM1 (0.57) | STIM1ORAI1ORAI2IL2ABL1 | |
| SCHEMBL12155497 | 0.78 | ABL1 (0.43) | IL2ALDH1A1HPGDABL1NPC1 | |
| SCHEMBL12155776 | 0.77 | SMN1; SMN2 (0.51) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL12155654 | 0.77 | STIM1 (0.57) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL12155798 | 0.77 | STIM1 (0.75) | STIM1ORAI1ORAI2IL2NPC1 | |
| SCHEMBL13730310 | 0.76 | IL2 (0.47) | STIM1ORAI1ORAI2IL2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9120751-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| US-9120751-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-09-01 | — | — | US | disclosed |