Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL771863 | 0.85 | S1PR1 (0.80) | S1PR1 | |
| SCHEMBL772674 | 0.83 | S1PR1 (0.75) | S1PR1 | |
| SCHEMBL772871 | 0.83 | S1PR1 (0.72) | S1PR1 | |
| SCHEMBL773590 | 0.83 | S1PR1 (0.80) | S1PR1 | |
| SCHEMBL772317 | 0.82 | S1PR1 (0.71) | S1PR1 | |
| SCHEMBL773373 | 0.82 | S1PR1 (0.77) | S1PR1 | |
| SCHEMBL774590 | 0.81 | S1PR1 (0.75) | S1PR1 | |
| SCHEMBL797866 | 0.81 | S1PR1 (0.74) | S1PR1 | |
| SCHEMBL773358 | 0.80 | S1PR1 (0.65) | S1PR1 | |
| SCHEMBL774852 | 0.80 | S1PR1 (0.70) | S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440554-A1 | PYRAZOLE OXADIAZOLE DERIVATIVES AS S1P1 AGONISTS | Merck Serono S.A. (CH) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142628-A1 | PYRAZOLE OXADIAZOLE DERIVATIVES AS S1P1 AGONISTS | MERCK SERONO S.A. (CH) | 2010-12-16 | — | — | WO | disclosed |