Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | LNPEP | Q9UIQ6 | 7/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19900116 | 0.83 | MAPT (0.57) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL18573835 | 0.83 | KDM4E (0.53) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL4119820 | 0.82 | MAPT (0.56) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL192100 | 0.77 | KDM4E (0.72) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL29375113 | 0.77 | KDM4E (0.72) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL61793 | 0.76 | MAPT (0.61) | MAPTKDM4EALDH1A1HPGDGAA | |
| Hydrochloric Acid SCHEMBL1223871 | 0.75 | KDM4E (0.70) | MAPTKDM4EALDH1A1HPGDGAA | |
| Hydrochloric Acid SCHEMBL7251305 | 0.75 | KDM4E (0.70) | MAPTKDM4EALDH1A1HPGDGAA | |
| Ammonia Solution, Strong SCHEMBL5311634 | 0.75 | KDM4E (0.70) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL5006583 | 0.75 | KDM4E (0.48) | MAPTKDM4EALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017035349-A1 | AMIDE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2017-03-02 | — | — | WO | disclosed |
| WO-2015130795-A1 | AMIDE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2015-09-03 | — | — | WO | disclosed |