Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058297 | 0.88 | SMN1; SMN2 (0.39) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058207 | 0.84 | NPSR1 (0.38) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058280 | 0.80 | NPSR1 (0.39) | SMN1; SMN2POLBLMNAKMT2AMAPT | |
| SCHEMBL17058105 | 0.78 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058119 | 0.77 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL11944663 | 0.77 | POLB (0.46) | SMN1; SMN2POLBLMNAMAPTALDH1A1 | |
| SCHEMBL17058560 | 0.76 | SMN1; SMN2 (0.38) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058168 | 0.76 | MAPT (0.40) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058143 | 0.76 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058542 | 0.73 | SMN1; SMN2 (0.33) | NPC1RAB9ASMN1; SMN2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |