Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058372 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL17057953 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL14899744 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL17058302 | 0.83 | NPC1 (0.48) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL17058486 | 0.82 | MAPT (0.42) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL17058311 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL17058118 | 0.80 | NPC1 (0.43) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL17058020 | 0.80 | GRM2 (0.38) | SMN1; SMN2LMNAPOLBKMT2AKDM4E | |
| SCHEMBL17058263 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL17057929 | 0.80 | POLB (0.42) | SMN1; SMN2RAB9ANPC1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |