Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058025 | 0.90 | SLC2A1 (0.31) | SLC2A1SLC2A3MCHR1 | |
| SCHEMBL11945290 | 0.85 | MAPT (0.38) | SMN1; SMN2LMNAALDH1A1POLBKMT2A | |
| SCHEMBL17058276 | 0.84 | SLC2A1 (0.34) | SMN1; SMN2LMNAALDH1A1POLBKMT2A | |
| SCHEMBL17058467 | 0.82 | NPSR1 (0.33) | RAB9ASMN1; SMN2ALDH1A1POLBSLC2A1 | |
| SCHEMBL17058382 | 0.81 | SLC2A1 (0.35) | SMN1; SMN2LMNAALDH1A1POLBKMT2A | |
| SCHEMBL17058015 | 0.81 | SLC2A1 (0.35) | SMN1; SMN2LMNAALDH1A1POLBKMT2A | |
| SCHEMBL17058510 | 0.80 | SLC2A1 (0.32) | SLC2A1SLC2A3MCHR1 | |
| SCHEMBL17058210 | 0.80 | — | — | |
| SCHEMBL17058202 | 0.80 | SLC2A1 (0.36) | SMN1; SMN2LMNAALDH1A1POLBKMT2A | |
| SCHEMBL17058205 | 0.80 | SLC2A1 (0.34) | RAB9ASMN1; SMN2LMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |