Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29547096 | 1.00 | EGFR (1.00) | EGFR | |
| Maleic Acid SCHEMBL29175077 | 0.97 | EGFR (0.93) | EGFR | |
| SCHEMBL17059201 | 0.91 | EGFR (1.00) | EGFR | |
| SCHEMBL18369569 | 0.90 | EGFR (0.85) | EGFR | |
| SCHEMBL17059273 | 0.88 | EGFR (1.00) | EGFR | |
| SCHEMBL18657445 | 0.86 | EGFR (0.76) | EGFR | |
| SCHEMBL17059257 | 0.86 | EGFR (1.00) | EGFR | |
| SCHEMBL17059227 | 0.86 | EGFR (1.00) | EGFR | |
| SCHEMBL17059294 | 0.86 | EGFR (0.79) | EGFR | |
| SCHEMBL30446009 | 0.85 | EGFR (0.74) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157391-A | Pharmaceutical composition comprising EGFR inhibitor and preparation method thereof | 上海海雁医药科技有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-107531678-B | EGFR inhibitor and pharmaceutically acceptable salts and polymorphs thereof and uses thereof | 上海海雁医药科技有限公司 | 2020-12-22 | — | — | CN | disclosed |
| CN-107531678-B | EGFR inhibitor and pharmaceutically acceptable salts and polymorphs thereof and uses thereof | 上海海雁医药科技有限公司 | 2020-12-22 | — | — | CN | disclosed |
| US-10561646-B2 | EGFR inhibitor and pharmaceutically acceptable salt and polymorph thereof, and use thereof | Shanghai Haiyan Pharmaceutical Technology Co. Ltd. (CN) | 2020-02-18 | — | — | US | disclosed |
| US-10561646-B2 | EGFR inhibitor and pharmaceutically acceptable salt and polymorph thereof, and use thereof | Shanghai Haiyan Pharmaceutical Technology Co. Ltd. (CN) | 2020-02-18 | — | — | US | disclosed |
| US-10561646-B2 | EGFR inhibitor and pharmaceutically acceptable salt and polymorph thereof, and use thereof | Shanghai Haiyan Pharmaceutical Technology Co. Ltd. (CN) | 2020-02-18 | — | — | US | disclosed |
| US-10435400-B2 | 2,4-disubstituted phenylene-1,5-diamine derivatives and applications thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom | Shanghai Haiyan Pharmaceutical Technology Co. Ltd. (CN) | 2019-10-08 | — | — | US | disclosed |
| US-20180319770-A1 | EGFR INHIBITOR AND PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPH THEREOF, AND USE THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2018-11-08 | — | — | US | disclosed |
| US-20180319770-A1 | EGFR INHIBITOR AND PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPH THEREOF, AND USE THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2018-11-08 | — | — | US | disclosed |
| EP-3327014-A1 | EGFR INHIBITOR AND PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPH THEREOF, AND USE THEREOF | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2018-05-30 | — | — | EP | disclosed |
| EP-3327014-A1 | EGFR INHIBITOR AND PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPH THEREOF, AND USE THEREOF | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2018-05-30 | — | — | EP | disclosed |
| EP-3327014-A1 | EGFR INHIBITOR AND PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPH THEREOF, AND USE THEREOF | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017016463-A1 | EGFR INHIBITOR AND PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPH THEREOF, AND USE THEREOF | 上海海雁医药科技有限公司 | 2017-02-02 | — | — | WO | disclosed |
| US-20170008889-A1 | 2,4-DISUBSTITUTED PHENYLENE-1,5-DIAMINE DERIVATIVES AND APPLICATIONS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | Shanghai Haiyan Pharmaceutical Technology Co. Ltd. (CN) | 2017-01-12 | — | — | US | disclosed |
| US-20170008889-A1 | 2,4-DISUBSTITUTED PHENYLENE-1,5-DIAMINE DERIVATIVES AND APPLICATIONS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | Shanghai Haiyan Pharmaceutical Technology Co. Ltd. (CN) | 2017-01-12 | — | — | US | disclosed |
| EP-3112364-A1 | 2,4-DISUBSTITUTED PHENYLENE-1,5-DIAMINE DERIVATIVES AND APPLICATIONS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | Shanghai Haiyan Pharmaceutical Technology Co. Ltd. (CN) | 2017-01-04 | — | — | EP | disclosed |
| WO-2015127872-A1 | 2,4-DISUBSTITUTED PHENYLENE-1,5-DIAMINE DERIVATIVES AND APPLICATIONS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | 上海海雁医药科技有限公司 | 2015-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319770-A1 | EGFR INHIBITOR AND PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPH THEREOF, AND USE THEREOF | EGFR, ERBB2, ERBB3 | EGFR 1/4885 |
| US-20170008889-A1 | 2,4-DISUBSTITUTED PHENYLENE-1,5-DIAMINE DERIVATIVES AND APPLICATIONS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | ERBB2, EGFR, ERBB3 | EGFR 2/4885 |
| US-10435400-B2 | 2,4-disubstituted phenylene-1,5-diamine derivatives and applications thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom | ERBB2, EGFR, ERBB3 | EGFR 2/4885 |
| US-10561646-B2 | EGFR inhibitor and pharmaceutically acceptable salt and polymorph thereof, and use thereof | EGFR, ERBB2, ERBB3 | EGFR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.