Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 8/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594948 | 0.83 | RIPK2 (0.66) | RIPK2KDRRETMAPK14PKMYT1 | |
| SCHEMBL2588825 | 0.83 | RIPK2 (0.64) | RIPK2KDRRETMAPK14PKMYT1 | |
| SCHEMBL2595819 | 0.79 | RIPK2 (0.64) | RIPK2KDRRETMAPK14PKMYT1 | |
| SCHEMBL2594978 | 0.77 | RIPK2 (0.75) | RIPK2KDRRETMAPK14PKMYT1 | |
| SCHEMBL2592798 | 0.76 | RIPK2 (0.64) | RIPK2KDRRETMAPK14PKMYT1 | |
| SCHEMBL2594527 | 0.76 | RIPK2 (0.67) | RIPK2KDRRETMAPK14PKMYT1 | |
| SCHEMBL2595969 | 0.76 | RIPK2 (0.65) | RIPK2KDRRETMAPK14PKMYT1 | |
| SCHEMBL2595104 | 0.76 | RIPK2 (0.65) | RIPK2KDRRETMAPK14PKMYT1 | |
| SCHEMBL14718858 | 0.76 | RIPK2 (0.72) | RIPK2KDRRETMAPK14PKMYT1 | |
| Gw559768X SCHEMBL2592805 | 0.75 | RIPK2 (1.00) | RIPK2KDRRETMAPK14PKMYT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | disclosed |