Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 16/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | RIPK3 | Q9Y572 | 7/20 | 0.56 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595096 | 0.91 | RIPK2 (0.57) | RIPK2KDRRIPK3RIPK1EGFR | |
| SCHEMBL2594915 | 0.90 | RIPK2 (0.62) | RIPK2KDRRIPK3RIPK1EGFR | |
| SCHEMBL2593034 | 0.89 | RIPK2 (0.56) | RIPK2KDRRIPK3RIPK1EGFR | |
| SCHEMBL2594950 | 0.88 | RIPK2 (0.54) | RIPK2KDRRIPK3RIPK1EGFR | |
| SCHEMBL2595656 | 0.85 | RIPK2 (0.62) | RIPK2KDRRIPK3RIPK1EGFR | |
| SCHEMBL12180631 | 0.84 | RIPK2 (0.59) | RIPK2KDRRIPK3RIPK1EGFR | |
| SCHEMBL2594624 | 0.84 | RIPK2 (0.66) | RIPK2KDRRIPK3RIPK1EGFR | |
| SCHEMBL12180643 | 0.84 | RIPK2 (0.60) | RIPK2KDRRIPK3RIPK1EGFR | |
| SCHEMBL2596178 | 0.83 | RIPK2 (0.57) | RIPK2KDRRIPK3RIPK1EGFR | |
| SCHEMBL2594962 | 0.82 | RIPK2 (0.61) | RIPK2KDRRIPK3RIPK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | disclosed |