Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 16/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059480 | 0.82 | RIPK2 (0.54) | RIPK2KDRRIPK3RIPK1BRAF | |
| SCHEMBL14718449 | 0.80 | RIPK2 (0.67) | RIPK2KDRRIPK3RIPK1BRAF | |
| SCHEMBL14718180 | 0.80 | RIPK2 (0.67) | RIPK2KDRRIPK3RIPK1BRAF | |
| SCHEMBL14717653 | 0.80 | RIPK2 (0.67) | RIPK2KDRRIPK3RIPK1BRAF | |
| SCHEMBL14717191 | 0.79 | RIPK2 (0.66) | RIPK2KDRRIPK3RIPK1BRAF | |
| SCHEMBL14717887 | 0.78 | RIPK2 (0.52) | RIPK2KDRRIPK3RIPK1BRAF | |
| SCHEMBL14718151 | 0.78 | RIPK2 (0.67) | RIPK2KDRRIPK3RIPK1BRAF | |
| SCHEMBL14730927 | 0.77 | RIPK2 (0.63) | RIPK2KDRRIPK3RIPK1BRAF | |
| SCHEMBL17059496 | 0.77 | RIPK2 (0.63) | RIPK2KDRRIPK3RIPK1BRAF | |
| SCHEMBL2589405 | 0.76 | RIPK2 (0.68) | RIPK2KDRRIPK3RIPK1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | disclosed |