Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 11/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | GAK | O14976 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.52 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
| ▸ | ULK1 | O75385 | 3/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.35 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595333 | 0.90 | RIPK2 (0.69) | RIPK2KCNH2GAKMAPK14LCK | |
| SCHEMBL2589389 | 0.84 | RIPK2 (0.67) | RIPK2KCNH2GAKMAPK14LCK | |
| SCHEMBL600928 | 0.82 | RIPK2 (0.65) | RIPK2KCNH2GAKMAPK14LCK | |
| SCHEMBL600382 | 0.78 | RIPK2 (0.53) | RIPK2KCNH2GAKMAPK14LCK | |
| SCHEMBL10123709 | 0.78 | RIPK2 (0.54) | RIPK2KCNH2GAKMAPK14LCK | |
| SCHEMBL600481 | 0.77 | RIPK2 (0.63) | RIPK2KCNH2GAKMAPK14LCK | |
| SCHEMBL12497160 | 0.76 | RIPK2 (0.55) | RIPK2KCNH2GAKMAPK14LCK | |
| SCHEMBL12496266 | 0.75 | RIPK2 (0.54) | RIPK2KCNH2GAKMAPK14LCK | |
| SCHEMBL12497191 | 0.75 | RIPK2 (0.56) | RIPK2KCNH2GAKMAPK14LCK | |
| SCHEMBL14717834 | 0.75 | RIPK2 (0.69) | RIPK2KCNH2GAKMAPK14LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | disclosed |