Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.58 |
| ▸ | JAK1 | P23458 | 12/20 | 0.58 |
| ▸ | AURKA | O14965 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17060898 | 0.91 | JAK3 (0.68) | JAK3JAK1AURKAJAK2AURKB | |
| SCHEMBL1741052 | 0.87 | JAK3 (0.52) | JAK3JAK1AURKAJAK2AURKB | |
| SCHEMBL29610425 | 0.87 | JAK3 (0.52) | JAK3JAK1AURKAJAK2AURKB | |
| SCHEMBL17060887 | 0.84 | BRD4 (0.56) | JAK3JAK1AURKAJAK2AURKB | |
| SCHEMBL340444 | 0.84 | JAK3 (0.49) | JAK3JAK1AURKAJAK2AURKB | |
| SCHEMBL340332 | 0.83 | JAK3 (0.49) | JAK3JAK1AURKAJAK2AURKB | |
| SCHEMBL29609992 | 0.82 | JAK3 (0.48) | JAK3JAK1AURKAJAK2AURKB | |
| SCHEMBL15389504 | 0.82 | JAK3 (0.48) | JAK3JAK1AURKAJAK2AURKB | |
| SCHEMBL15389507 | 0.82 | JAK3 (0.48) | JAK3JAK1AURKAJAK2AURKB | |
| SCHEMBL15389682 | 0.82 | JAK1 (0.48) | JAK3JAK1AURKAJAK2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389372-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2015-09-09 | — | — | EP | claimed |